Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation.

@article{Dulla2013GlutamateBI,
  title={Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation.},
  author={Chris G Dulla and Hiroaki Tani and Julia A. Brill and Richard J. Reimer and John R. Huguenard},
  journal={Neurobiology of disease},
  year={2013},
  volume={49},
  pages={232-46}
}
Cortical malformations can cause intractable epilepsy, but the underlying epileptogenic mechanisms are poorly understood. We used high-speed glutamate biosensor imaging to ask how glutamatergic signaling is altered in cortical malformations induced by neonatal freeze-lesions (FL). In non-lesion neocortical slices from 2 to 8week old rats, evoked glutamate signals were symmetrical in the medio-lateral axis and monotonic, correlating with simple, brief (≈50ms) local field potentials (LFPs). By… CONTINUE READING