Glutamate and tumor-associated epilepsy: glial cell dysfunction in the peritumoral environment.

@article{Buckingham2013GlutamateAT,
  title={Glutamate and tumor-associated epilepsy: glial cell dysfunction in the peritumoral environment.},
  author={Susan C Buckingham and Stefanie Robel},
  journal={Neurochemistry international},
  year={2013},
  volume={63 7},
  pages={696-701}
}
Seizures are a serious and debilitating co-morbidity of primary brain tumors that affect most patients, yet their etiology is poorly understood. In many CNS pathologies, including epilepsy and brain injury, high levels of extracellular glutamate have been implicated in seizure generation. It has been shown that gliomas release neurotoxic levels of glutamate through their high expression of system xc-. More recently it was shown that the surrounding peritumoral cortex is spontaneously… CONTINUE READING
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