Glutamate and the pathophysiology of hypoxic--ischemic brain damage.

@article{Rothman1986GlutamateAT,
  title={Glutamate and the pathophysiology of hypoxic--ischemic brain damage.},
  author={Steven M. Rothman and John W. Olney},
  journal={Annals of neurology},
  year={1986},
  volume={19 2},
  pages={105-11}
}
Information obtained over the past 25 years indicates that the amino acid glutamate functions as a fast excitatory transmitter in the mammalian brain. Studies completed during the last 15 years have also demonstrated that glutamate is a powerful neurotoxin, capable of killing neurons in the central nervous system when its extracellular concentration is sufficiently high. Recent experiments in a variety of preparations have shown that either blockade of synaptic transmission or the specific… CONTINUE READING
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