Glutamate and the biology of gliomas.

  title={Glutamate and the biology of gliomas.},
  author={John Frederick de Groot and Harald Sontheimer},
  volume={59 8},
Several important and previously unrecognized roles for the neurotransmitter glutamate in the biology of primary brain tumors have recently been elucidated. Glutamate is produced and released from glioma cells via the system x(c) (-) cystine glutamate transporter as a byproduct of glutathione synthesis. Glutamate appears to play a central role in the malignant phenotype of glioma via multiple mechanisms. By binding to peritumoral neuronal glutamate receptors, glutamate is responsible for… CONTINUE READING


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