Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation.

@article{Chambers1999GlutamateAP,
  title={Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation.},
  author={R. Andrew Chambers and J. Douglas Bremner and Bita Moghaddam and Steven M. Southwick and Dennis S. Charney and John H. Krystal},
  journal={Seminars in clinical neuropsychiatry},
  year={1999},
  volume={4 4},
  pages={274-81}
}
Dissociative cognitive and perceptual alterations commonly occur at the time of traumatization and as an enduring feature of post-traumatic stress disorder (PTSD). After stress exposure, dissociative symptoms are a predictor of the development of PTSD. Recent preclinical data suggest that stress stimulates the cortico-limbic release of glutamate. The glutamate that is released during stress in animal models influences behavior, induces a variety of changes in neural plasticity that may have… CONTINUE READING

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