Glutamate and calcium uptake in astrocytes after acute lead exposure.

@article{Raunio2001GlutamateAC,
  title={Glutamate and calcium uptake in astrocytes after acute lead exposure.},
  author={S Raunio and Hanna T{\"a}hti},
  journal={Chemosphere},
  year={2001},
  volume={44 3},
  pages={355-9}
}
The neurotoxicity of lead is well known, but the exact mechanisms of its toxicity are not solved yet. Disturbances in glutamate homeostasis of neural tissue and interactions of lead with calcium metabolism have been considered as a potential mechanism. In the present study, we evaluate the acute effect of lead exposure by studying glutamate uptake, as well as calcium influx and intracellular lead in cultured rat cerebellar astrocytes. Glutamate uptake and calcium influx were evaluated with… CONTINUE READING

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