Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice.

@article{Park2000GlutamateAA,
  title={Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice.},
  author={C H Park and Se Hoon Choi and Yongxu Piao and Sunnie S Kim and Young Jae Lee and Hwang Soo Kim and S J Jeong and J C Rah and Je Hoon Seo and Josephine H Lee and Kiran Chang and Yeon joo Jung and Young Ho Suh},
  journal={Toxicology letters},
  year={2000},
  volume={115 2},
  pages={117-25}
}
We examined the effects of systemic administration of monosodium glutamate (MSG) or aspartate (ASP) on the memory retention and neuronal damage in the brains of adult mice. Compared with the control mice, a single intraperitoneal injection of either 4.0 mg/g MSG or 0.5 mg/g ASP after acquisition trial significantly shortened the response latency in the passive avoidance test, accompanying by the transient weight loss. Histopathological analysis of the brains of these mice revealed that neurons… CONTINUE READING
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