Glutamate and Parkinson’s disease

  title={Glutamate and Parkinson’s disease},
  author={Fabio Blandini and Richard H. P. Porter and J Timothy Greenamyre},
  journal={Molecular Neurobiology},
Altered glutamatergic neurotransmission and neuronal metabolic dysfunction appear to be central to the pathophysiology of Parkinson’s disease (PD). The substantia nigra pars compacta—the area where the primary pathological lesion is located—is particularly exposed to oxidative stress and toxic and metabolic insults. A reduced capacity to cope with metabolic demands, possibly related to impaired mitochondrial function, may render nigral neurons highly vulnerable to the effects of glutamate… CONTINUE READING