Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments

  title={Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments},
  author={John H. Krystal and Gerard S Sanacora and Hilary Blumberg and Amit Anand and Dennis S. Charney and Gerard J. Marek and C Neill Epperson and Amanda F Goddard and Graeme F. Mason},
  journal={Molecular Psychiatry},
Glutamate and γ-amino butyric acid (GABA) systems are emerging as targets for development of medications for mood disorders. There is increasing preclinical and clinical evidence that antidepressant drugs directly or indirectly reduce N-methyl-D-aspartate glutamate receptor function. Drugs that reduce glutamatergic activity or glutamate receptor-related signal transduction may also have antimanic effects. Recent studies employing magnetic resonance spectroscopy also suggest that unipolar, but… CONTINUE READING
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