Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation

@inproceedings{Kimura2013GlutamateAD,
  title={Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation},
  author={Ryota Kimura and Atsushi Kasamatsu and Tomoyoshi Koyama and Chonji Fukumoto and Yukinao Kouzu and Morihiro Higo and Yosuke Endo-Sakamoto and Katsunori Ogawara and Masashi Shiiba and Hideki Tanzawa and Katsuhiro Uzawa},
  booktitle={BMC Cancer},
  year={2013}
}
Glutamate decarboxylase 1 (GAD1), a rate-limiting enzyme in the production of γ-aminobutyric acid (GABA), is found in the GABAergic neurons of the central nervous system. Little is known about the relevance of GAD1 to oral squamous cell carcinoma (OSCC). We investigated the expression status of GAD1 and its functional mechanisms in OSCCs. We evaluated GAD1 mRNA and protein expressions in OSCC-derived cells using real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR… CONTINUE READING
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