Glutamate Transporters/Na+, K+-ATPase Involving in the Neuroprotective Effect as a Potential Regulatory Target of Glutamate Uptake

Abstract

The glutamate (Glu) transporters GLAST and GLT-1, as the two most important transporters in brain tissue, transport Glu from the extracellular space into the cell protecting against Glu toxicity. Furthermore, GLAST and GLT-1 are sodium-dependent Glu transporters (GluTs) that rely on sodium and potassium gradients generated principally by Na+, K+-ATPase to generate ion gradients that drive Glu uptake. There is an interaction between Na+, K+-ATPase and GluTs to modulate Glu uptake, and Na+, K+-ATPase α, β or γ subunit can be directly coupled to GluTs, co-localizing with GLAST or GLT-1 in vivo to form a macromolecular complex and operate as a functional unit to regulate glutamatergic neurotransmission. Therefore, GluTs/Na+, K+-ATPase may be involved in the neuroprotective effect as a potential regulatory target of Glu uptake in neurodegenerative diseases induced by Glu-mediated neurotoxicity as the final common pathway.

DOI: 10.1007/s12035-014-9071-4

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@article{Zhang2014GlutamateTK, title={Glutamate Transporters/Na+, K+-ATPase Involving in the Neuroprotective Effect as a Potential Regulatory Target of Glutamate Uptake}, author={Li-Nan Zhang and Yong-Jun Sun and Li-xue Wang and Zi-bin Gao}, journal={Molecular Neurobiology}, year={2014}, volume={53}, pages={1124-1131} }