Glutamate Transporters/Na+, K+-ATPase Involving in the Neuroprotective Effect as a Potential Regulatory Target of Glutamate Uptake

@article{Zhang2014GlutamateTK,
  title={Glutamate Transporters/Na+, K+-ATPase Involving in the Neuroprotective Effect as a Potential Regulatory Target of Glutamate Uptake},
  author={Li-Nan Zhang and Yong-Jun Sun and Li-xue Wang and Zi-bin Gao},
  journal={Molecular Neurobiology},
  year={2014},
  volume={53},
  pages={1124-1131}
}
The glutamate (Glu) transporters GLAST and GLT-1, as the two most important transporters in brain tissue, transport Glu from the extracellular space into the cell protecting against Glu toxicity. Furthermore, GLAST and GLT-1 are sodium-dependent Glu transporters (GluTs) that rely on sodium and potassium gradients generated principally by Na+, K+-ATPase to generate ion gradients that drive Glu uptake. There is an interaction between Na+, K+-ATPase and GluTs to modulate Glu uptake, and Na+, K… CONTINUE READING