Glutamate Receptor GluR3 Antibodies and Death of Cortical Cells

@article{He1998GlutamateRG,
  title={Glutamate Receptor GluR3 Antibodies and Death of Cortical Cells},
  author={Xiao-ping He and Manisha B. Patel and Karl D. Whitney and Sridevi Janumpalli and Andrea Joan Tenner and James O. McNamara},
  journal={Neuron},
  year={1998},
  volume={20},
  pages={153-163}
}

• Xiao-ping He, Manisha B. Patel, +3 authors James O. McNamara
• Published 1998 in Neuron
• DOI:10.1016/S0896-6273(00)80443-2

Rasmussen's encephalitis (RE), a childhood disease characterized by epileptic seizures associated with progressive destruction of a single cerebral hemisphere, is an autoimmune disease in which one of the autoantigens is a glutamate receptor, GluR3. The improvement of some affected children following plasma exchange that removed circulating GluR3 antibodies (anti-GluR3) suggested that anti-GluR3 gained access to the central nervous system where it exerted deleterious effects. Here, we… CONTINUE READING

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