Glutamate Promotes Cell Growth by EGFR Signaling on U-87MG Human Glioblastoma Cell Line

@article{Schunemann2009GlutamatePC,
  title={Glutamate Promotes Cell Growth by EGFR Signaling on U-87MG Human Glioblastoma Cell Line},
  author={Daniel Pretto Schunemann and Ivana Grivicich and Andr{\'e}a Regner and Lisiane Freitas Leal and Daniela Romani de Ara{\'u}jo and Geraldo Pereira Jotz and Carlos Alexandre Fedrigo and Daniel Simon and Adriana Brondani da Rocha},
  journal={Pathology & Oncology Research},
  year={2009},
  volume={16},
  pages={285-293}
}
Accumulating evidences suggest that glutamate plays a key role in the proliferation and invasion of malignant glioblastoma (GBM) tumors. It has been shown that GBM cells release and exploit glutamate for proliferation and invasion through AMPA glutamate receptors. Additionally, amplification of the epidermal growth factor receptor (EGFR) gene occurs in 40–50% of GBM. Since, PI3K/Akt is considered one of the main intracellular pathways involved in EGFR activation, AKT functions could trigger… CONTINUE READING

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Accumulating evidences suggest that glutamate plays a key role in the proliferation and invasion of malignant glioblastoma ( GBM ) tumors .
For these purpose , we treated the U-87MG cell line with 5 to 200 mM of glutamate and assessed the number of viable cells by trypan blue dye exclusion test .
It has been shown that GBM cells release and exploit glutamate for proliferation and invasion through AMPA glutamate receptors .
It has been shown that GBM cells release and exploit glutamate for proliferation and invasion through AMPA glutamate receptors .
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