Glutamate-Mediated Down-Regulation of the Multidrug-Resistance Protein BCRP/ABCG2 in Porcine and Human Brain Capillaries.

@article{Salvamoser2015GlutamateMediatedDO,
  title={Glutamate-Mediated Down-Regulation of the Multidrug-Resistance Protein BCRP/ABCG2 in Porcine and Human Brain Capillaries.},
  author={Josephine D. Salvamoser and Janine Avemary and Hiram Luna-Munguia and Bettina Pascher and Thekla Getzinger and T. Pieper and Manfred Kudernatsch and Gerhard Josef Kluger and Heidrun Potschka},
  journal={Molecular pharmaceutics},
  year={2015},
  volume={12 6},
  pages={2049-60}
}
Breast cancer resistance protein (BCRP) functions as a major molecular gatekeeper at the blood-brain barrier. Considering its impact on access to the brain by therapeutic drugs and harmful xenobiotics, it is of particular interest to elucidate the mechanisms of its regulation. Excessive glutamate concentrations have been reported during epileptic seizures or as a consequence of different brain insults including brain ischemia. Previously, we have demonstrated that glutamate can trigger an… CONTINUE READING
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