Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point

  title={Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point},
  author={Hong Q Smith and Changhong Li and Charles A. Stanley and Thomas James Smith},
  journal={Neurochemical Research},
In-vitro, glutamate dehydrogenase (GDH) catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG). GDH is found in all organisms, but in animals is allosterically regulated by a wide array of metabolites. For many years, it was not at all clear why animals required such complex control. Further, in both standard textbooks and some research publications, there has been some controversy as to the directionality of the reaction. Here we review recent work demonstrating… CONTINUE READING

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Glutamate dehydrogenase: equilibrium and kinetic studies

  • CM Limuti
  • Department of Biochemistry,
  • 1983
Highly Influential
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