• Corpus ID: 25753607

Glutamate Antagonists, Steroids, and Antioxidants as Therapeutic Options for Hearing Loss and Tinnitus and the Use of an Inner Ear Drug Delivery System.

@article{Seidman1998GlutamateAS,
  title={Glutamate Antagonists, Steroids, and Antioxidants as Therapeutic Options for Hearing Loss and Tinnitus and the Use of an Inner Ear Drug Delivery System.},
  author={Seidman},
  journal={The international tinnitus journal},
  year={1998},
  volume={4 2},
  pages={
          148-154
        }
}
  • Seidman
  • Published 1998
  • Medicine
  • The international tinnitus journal
A wealth of anecdotal, empirica], and double-blind placebo-controlled data exists on medicines that may have a beneficial role in the management of patients with tinnitus. Tinnitus is a symptom that affects between 40 and 45 million Americans alone; this represents approximately 14% of the US population. Data exist for Japan (population: 125,732,794), Europe (population: 503 million), and Australia (population: 18,426,900), and estimates suggest that tinnitus affects a similar percentage of… 
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51 Citations
Background Citations
10
Methods Citations
1

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[Physiopathological mechanisms in tinnitus generation and persistence].
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Connections to associative cortex and limbic-amigdala area using the non-classical auditory system explain the presence of hyperacusis, anxiety or depression, factors that increase the severity of tinnitus.
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References

SHOWING 1-10 OF 42 REFERENCES
Neuroprotective Drug Therapy: A Medical and Pharmacological Treatment for Tinnitus Control.
  • Shulman
  • Medicine
    The international tinnitus journal
  • 1997
TLDR
The goal of this article is to introduce to the neurootologist or otologist and other professionals attempting tinnitus control neuroprotective drug therapies that are being applied to such central nervous system pathological processes as ischemia, trauma, hemorrhage, and neurodegeneration.
Caroverine in tinnitus treatment. A placebo-controlled blind study.
TLDR
The results confirm the working hypothesis on the genesis of cochlear-synaptic tinnitus that caroverine acted as a potent competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazone-proprionic acid (AMPA) receptor antagonist and, in higher dosages, a non-competitive N- methyl-d-aspartate (NMDA) antagonist.
Effects of superoxide dismutase and U74389G on acute trimethyltin-induced cochlear dysfunction.
TLDR
Results suggest that ROS formation may be involved in acute TMT-induced CAP disruption, for which PEG.SOD, but not U74389G, provides partial protection.
The Protective Effects of Allopurinol and Superoxide Dismutase on Noise-Induced Cochlear Damage
TLDR
Findings show that SOD-PEG and allopurinol may preserve cochlear sensitivity associated with noise exposure, which suggests that noise-induced damage to the cochlea may be related to the activity of FORs.
Glutamate neurotoxicity in the developing rat cochlea is antagonized by kynurenic acid and MK-801
Oxidative stress, glutamate, and neurodegenerative disorders.
TLDR
Two broad mechanisms--oxidative stress and excessive activation of glutamate receptors--are converging and represent sequential as well as interacting processes that provide a final common pathway for cell vulnerability in the brain.
Glutamate neurotoxicity in the cochlea: a possible consequence of ischaemic or anoxic conditions occurring in ageing.
TLDR
Some of the cochlear damage that occur with ageing, especially the loss of the radial afferent fibres and type I ganglion cells, might well be attributed to glutamate excitotoxicity linked to vascular atrophy.
Glutathione protection against gentamicin ototoxicity depends on nutritional status
Effect of transtympanic injection of steroids on cochlear blood flow, auditory sensitivity, and histology in the guinea pig.
TLDR
The results suggest that transtympanic steroid application is not likely to be detrimental to the inner ear, and the increase in blood flow may indicate a possible mechanism accounting for the pharmacologic effects of steroids in the innerEar.
Protection of both auditory hair cells and auditory neurons from cisplatin induced damage.
TLDR
The combination of brain derived neurotrophic factor (BDNF) with D-met has shown that both auditory neurons and auditory hair cells can be protected from cisplatin induced damage in vitro.
...
...