Glutamate 268 regulates transport probability of the anion/proton exchanger ClC-5.

Abstract

The Cl(-)/H(+) exchange mediated by ClC transporters can be uncoupled by external SCN(-) and mutations of the proton glutamate, a conserved residue at the internal side of the protein. We show here for the mammalian ClC transporter ClC-5 that acidic internal pH led to a greater increase in currents upon exchanging extracellular Cl(-) for SCN(-). However… (More)
DOI: 10.1074/jbc.M111.298265

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@article{Grieschat2012Glutamate2R, title={Glutamate 268 regulates transport probability of the anion/proton exchanger ClC-5.}, author={Matthias Grieschat and Alexi K. Alekov}, journal={The Journal of biological chemistry}, year={2012}, volume={287 11}, pages={8101-9} }