Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury.

  title={Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury.},
  author={Michael J. Hudspith},
  journal={British journal of anaesthesia},
  volume={78 6},
  • M. Hudspith
  • Published 1 June 1997
  • Biology
  • British journal of anaesthesia
Glutamate is the major excitatory amino acid (EAA) neurotransmitter in the central nervous system (CNS). 78 EAA neurones and synapses are distributed widely throughout the CNS, 36 231 but they are concentrated particularly in the hippocampus, 91 the outer layer s of the cer ebr alor tex 91 and the substantia gelatinosa of the spinal cord. 194 Within these regions EAA play key roles in physiological processes including learning and memory (and hence awareness under anaesthesia), central pain… 

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