Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.

@article{Preitner2009Glut9IA,
  title={Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.},
  author={Fr{\'e}d{\'e}ric Preitner and Olivier Bonny and Alexandra Laverri{\`e}re and S Macarena Rotman and Dmitri Firsov and Anabela da Costa and Salima Metref and Bernard Thorens},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 36},
  pages={
          15501-6
        }
}
Elevated plasma urate levels are associated with metabolic, cardiovascular, and renal diseases. Urate may also form crystals, which can be deposited in joints causing gout and in kidney tubules inducing nephrolithiasis. In mice, plasma urate levels are controlled by hepatic breakdown, as well as, by incompletely understood renal processes of reabsorption and secretion. Here, we investigated the role of the recently identified urate transporter, Glut9, in the physiological control of urate… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 76 CITATIONS, ESTIMATED 56% COVERAGE

137 Citations

01020'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 137 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Humanrenalorganicaniontransporter 4 operates as an asymmetric urate transporter

  • SteinD HagosY, BurckhardtG UgeleB, BahnA
  • J Am Soc Nephrol
  • 2007

Similar Papers

Loading similar papers…