Glucuronidation of linoleic acid diols by human microsomal and recombinant UDP-glucuronosyltransferases: identification of UGT2B7 as the major isoform involved.

@article{Jude2001GlucuronidationOL,
  title={Glucuronidation of linoleic acid diols by human microsomal and recombinant UDP-glucuronosyltransferases: identification of UGT2B7 as the major isoform involved.},
  author={Anthony R Jude and Joanna M. Little and Piotr J. Czernik and Thomas R. Tephly and David F. Grant and Anna Radomińska-Pandya},
  journal={Archives of biochemistry and biophysics},
  year={2001},
  volume={389 2},
  pages={176-86}
}
Recent reports suggest that linoleic acid (LA) epoxides and diols are associated with important physiological, pharmacological, and pathological events in vivo. We have shown recently that LA-diols are excellent substrates for human liver microsomal UDP-glucuronosyltransferases (UGTs); however, it is not known if other human tissues glucuronidate LA-diols or which UGT isozyme(s) is involved. The present studies with human intestinal microsomes indicate that glucuronidation of LA-diols occurs… CONTINUE READING

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