Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes.

  title={Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes.},
  author={Keith R Kaderlik and Gerard J. Mulder and Robert J Turesky and Nicholas P. Lang and Candee Teitel and Michael Chiarelli and Fred F. Kadlubar},
  volume={15 8},
The food-borne carcinogenic and mutagenic heterocyclic aromatic amines undergo bioactivation to the corresponding N-hydroxy (OH)-arylamines and the subsequent N-glucuronidation of these metabolites is regarded as an important detoxification reaction. In this study, the rates of glucuronidation for the N-OH derivatives of 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) and 2-amino… CONTINUE READING


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