Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells.

@article{Chang2005GlucuronidationAT,
  title={Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells.},
  author={Jae Ho. Chang and Leslie Z Benet},
  journal={Molecular pharmaceutics},
  year={2005},
  volume={2 5},
  pages={428-34}
}
Formation and transport of glucuronide metabolites were studied in LLC-PK1 cells. Glucuronidation of 17beta-estradiol, 1-naphthol, mycophenolic acid, and 4-methylumbelliferone was examined in microsomes prepared from LLC-PK1 cells, human livers, human kidneys, and human intestines. The rate of glucuronide metabolite formation observed with LLC-PK1 microsomes was comparable to rates observed with various human tissue microsomes. The fate of the glucuronide metabolite formed in the LLC-PK1 cells… CONTINUE READING