Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes.

@article{Vaidyanathan2002GlucuronidationAS,
  title={Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes.},
  author={Jaya Bharathi Vaidyanathan and Thomas Walle},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 8},
  pages={897-903}
}
(-)-Epicatechin (EC) is one of the flavonoids present in green tea, suggested to have chemopreventive properties in cancer. However, its bioavailability is not clearly understood. In the present study, we determined the metabolism of EC, focusing on its glucuronic acid and sulfate conjugation using human liver and intestinal microsomes and cytosol as well as recombinant UDP-glucuronosyltransferase (UGT) and sulfotransferase (SULT) isoforms in comparison with that occurring in the rat… CONTINUE READING

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