Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver.

@article{Linster2006GlucuronateTP,
  title={Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver.},
  author={Carole L. Linster and Emile van Schaftingen},
  journal={The FEBS journal},
  year={2006},
  volume={273 7},
  pages={1516-27}
}
The conversion of UDP-glucuronate to glucuronate, usually thought to proceed by way of glucuronate 1-phosphate, is a site for short-term regulation of vitamin C synthesis by metyrapone and other xenobiotics in isolated rat hepatocytes. Our purpose was to explore the mechanism of this effect in cell-free systems. Metyrapone and other xenobiotics stimulated, by approximately threefold, the formation of glucuronate from UDP-glucuronate in liver extracts enriched with ATP-Mg, but did not affect the… CONTINUE READING