Glucosylation Drives the Innate Inflammatory Response to Clostridium difficile Toxin A.

Abstract

Clostridium difficile is a major, life-threatening hospital-acquired pathogen that causes mild to severe colitis in infected individuals. The tissue destruction and inflammation which characterize C. difficile infection (CDI) are primarily due to the Rho-glucosylating toxins A and B. These toxins cause epithelial cell death and induce robust inflammatory… (More)
DOI: 10.1128/IAI.00327-16

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Cite this paper

@article{Cowardin2016GlucosylationDT, title={Glucosylation Drives the Innate Inflammatory Response to Clostridium difficile Toxin A.}, author={Carrie A Cowardin and Brianna M Jackman and Zannatun Noor and Stacey L. Burgess and Andrew L Feig and William A Petri}, journal={Infection and immunity}, year={2016}, volume={84 8}, pages={2317-23} }