Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix

  title={Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix},
  author={David R. Sell and Klaus M. Biemel and Oliver Reihl and Markus O. Lederer and Christopher M. Strauch and Vincent M Monnier},
  journal={Journal of Biological Chemistry},
  pages={12310 - 12315}
The extracellular matrix in most tissues is characterized by progressive age-related stiffening and loss of proteolytic digestibility that are accelerated in diabetes and can be duplicated by the nonenzymatic reaction of reducing sugars and extracellular matrix proteins. However, most cross-links of the Maillard reaction described so far are present in quantities too low to account for these changes. Here we have determined in human skin and glomerular basement membrane (GBM) collagen the… 

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