Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia.

@article{Wambolt1999GlucoseUA,
  title={Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia.},
  author={Richard B. Wambolt and S L Henning and D R English and Yulia Dyachkova and Gary D Lopaschuk and Michael F. Allard},
  journal={Journal of molecular and cellular cardiology},
  year={1999},
  volume={31 3},
  pages={
          493-502
        }
}
We undertook this study to determine if the metabolism of exogenous glucose and glycogen in hypertrophied hearts differed from that in normal hearts during severe ischemia. Thus, rates of glycolysis (3H2O production) and oxidation (14CO2 production) from exogenous glucose and glycogen were measured in isolated working control (n = 13) and hypertrophied (n = 12) hearts from sham-operated and aortic-banded rats during 40 min of severe low-flow ischemia. Hearts, in which glycogen was prelabelled… CONTINUE READING

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