Glucose uptake pathway-specific regulation of synthesis of neotrehalosadiamine, a novel autoinducer produced in Bacillus subtilis.

@article{Inaoka2007GlucoseUP,
  title={Glucose uptake pathway-specific regulation of synthesis of neotrehalosadiamine, a novel autoinducer produced in Bacillus subtilis.},
  author={Takashi Inaoka and Kozo Ochi},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 1},
  pages={65-75}
}
Neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose; NTD) is an amino-sugar antibiotic produced by several Bacillus species that functions as an autoinducer by activating its own biosynthetic operon, ntdABC. We previously reported that the introduction of a certain rpoB mutation (rpoB5) into Bacillus subtilis enables the cells to overproduce NTD. B. subtilis mini-Tn10 transposant libraries have been screened for genes that affect NTD production. Inactivation of ccpA, which… CONTINUE READING
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