Glucose transporter polymorphisms are associated with clear-cell renal carcinoma.

  title={Glucose transporter polymorphisms are associated with clear-cell renal carcinoma.},
  author={Tobias Page and Andrea Dawn Hodgkinson and Martin Ollerenshaw and John C Hammonds and A. G. Demaine},
  journal={Cancer genetics and cytogenetics},
  volume={163 2},
Clear-cell renal cell carcinoma (CCRCC) is identified by abundant glycogen-rich cytoplasm, due to the aberrant influx and storage of glucose. The objective was to investigate the frequency of polymorphisms of the facilitative glucose transporter (GLUT1). GLUT1 is a downstream target of Hypoxia-inducible factor (HIF-1alpha), a mediator of hypoxia-controlled angiogenesis. In this study, we examine the allelic frequency of polymorphisms in the promoter and the second intron of the GLUT1 gene… CONTINUE READING
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