Glucose transport and glucose transporters in muscle and their metabolic regulation.

  title={Glucose transport and glucose transporters in muscle and their metabolic regulation.},
  author={Amira Klip and Michel R. P{\^a}quet},
  journal={Diabetes care},
  volume={13 3},
Skeletal muscle is the primary tissue responsible for insulin-dependent glucose uptake in vivo; therefore, glucose uptake by this tissue plays an important role in determining glycemia. Glucose uptake in muscle occurs by a system of facilitated diffusion involving at least two distinct glucose transporters, GLUT-1 and GLUT-4. Both bind the fungal metabolite and inhibitor of glucose transport cytochalasin B. In human skeletal muscle, both types of transporters are detected immunologically, and… CONTINUE READING
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