Glucose tolerance, insulin secretion and peripheral sensitivity in thalassaemia major.

@article{Arrigo1998GlucoseTI,
  title={Glucose tolerance, insulin secretion and peripheral sensitivity in thalassaemia major.},
  author={Teresa Arrigo and Giuseppe Crisafulli and Anna Meo and M Sturiale and Fortunato Lombardo and Marco Miceli and Domenico Cucinotta and Francesco Paolo De Luca},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  year={1998},
  volume={11 Suppl 3},
  pages={863-6}
}
Glyco-metabolic status was evaluated in 29 pubertal homozygous thalassaemics aged from 17 to 42 years and in 12 age-matched healthy subjects. Diagnosis of diabetes mellitus was assessed in 4 patients (13.8%), who became diabetic after the age of 18 years. With respect to controls non-diabetic patients exhibited significantly higher fasting plasma glucose levels and more sustained glycemic responses to oral glucose tolerance test, whereas their overall insulin output was significantly lower… CONTINUE READING

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