Glucose-stimulated insulin secretion from rat islets of Langerhans is independent of mitogen-activated protein kinase activation.

@article{Burns1997GlucosestimulatedIS,
  title={Glucose-stimulated insulin secretion from rat islets of Langerhans is independent of mitogen-activated protein kinase activation.},
  author={Chris Burns and Simon James Howell and Peter Martin Jones and Shanta J Persaud},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={239 2},
  pages={
          447-50
        }
}
The role played by mitogen-activated protein kinases (MAPKs) in the regulation of insulin secretion from adult rat islets of Langerhans was investigated by examining the effects of glucose, forskolin and 4beta phorbol myristate acetate (PMA) on islet MAPK activity and by measuring insulin secretion from islets in response to these agonists after inhibition of MAPK by PD 098059 (PD). Glucose (20mM) had a small (<2-fold) stimulatory effect on MAPK activity in isolated islets, and this was… CONTINUE READING