Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.

@article{ChaMolstad2009GlucosestimulatedEO,
  title={Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.},
  author={Hyunjoo Cha-Molstad and Geetu Saxena and Junqin Chen and Anath Shalev},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 25},
  pages={16898-905}
}
Recently, we identified Txnip (thioredoxin-interacting protein) as a mediator of glucotoxic beta cell death and discovered that lack of Txnip protects against streptozotocin- and obesity-induced diabetes by preventing beta cell apoptosis and preserving endogenous beta cell mass. Txnip has therefore become an attractive target for diabetes therapy, but although we have found that txnip transcription is highly induced by glucose through a unique carbohydrate response element, the factors… CONTINUE READING
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