Glucose starvation stimulates Zn2+ toxicity in cultures of cerebellar granule neurons.

Abstract

Zinc chloride (0.02 mM, 3h) did not have any influence on the survival of cerebellar granule neurons (CGNs) incubated in balanced salt solution (BSS). However, in the absence of glucose ZnCl(2) caused severe neuronal damage, decreasing cell survival to 12±2%. Either the blockade of ionotropic glutamate NMDA-receptors with MK-801 or APV or supplementation… (More)
DOI: 10.1016/j.brainresbull.2011.10.017

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