Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y.

  title={Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y.},
  author={Shinji Muroya and Toshihiko Yada and Seiji Shioda and Morikuni Takigawa},
  journal={Neuroscience letters},
  volume={264 1-3},
Glucose is known to regulate the activity of the hypothalamic feeding centers. Neuropeptide Y (NPY)-containing neurons in the hypothalamic arcuate nucleus (ARC) have been implicated in the stimulation of feeding. We examined the presence of glucose-sensitive neurons in the ARC and their coincidence with NPY-containing neurons. Cytosolic Ca2+ concentration ([Ca2+]i) in single ARC neurons isolated from rat hypothalamus was measured with fura-2 fluorescence imaging; the cells were then stained… CONTINUE READING


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