Glucose sensing electrode system based on polymeric microneedles


Microneedles are largely applied in biomedicine, both in diagnostics and therapeutics, since they can be considered the perfect interface between patient and sensing/dispensing devices. In this paper, we present an electro-chemical biosensor based on polymeric microneedles array for the measure of glucose level in interstitial fluids. The microneedles array has been fabricated by photolithography of a polymer, PolyEthylene Glycol DiAcrylate hydrogel, mixed with an enzyme, Glucose oxidase, and a redox mediator, the Vynilferrocene. The microneedles array acts as a working electrode when gold plated by sputtering and their tips have been etched to create a sensitive area. The redox reaction with glucose creates a charge transfer, enhanced by the redox mediator, resulting in a current proportional to the glucose concentration.

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@article{Dardano2016GlucoseSE, title={Glucose sensing electrode system based on polymeric microneedles}, author={Principia Dardano and Alessandro Cali{\`o} and Vincenza Di Palma and Maria Fortuna Bevilacqua and Andrea Di Matteo and Luca De Stefano}, journal={2016 IEEE Sensors Applications Symposium (SAS)}, year={2016}, pages={1-5} }