Glucose sensing and the pathogenesis of obesity and type 2 diabetes

  title={Glucose sensing and the pathogenesis of obesity and type 2 diabetes},
  author={Bernard Thorens},
  journal={International Journal of Obesity},
The control of body weight and of blood glucose concentrations depends on the exquisite coordination of the function of several organs and tissues, in particular the liver, muscle and fat. These organs and tissues have major roles in the use and storage of nutrients in the form of glycogen or triglycerides and in the release of glucose or free fatty acids into the blood, in periods of metabolic needs. These mechanisms are tightly regulated by hormonal and nervous signals, which are generated by… CONTINUE READING
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