Glucose repression in Streptomyces coelicolor A3(2): a likely regulatory role for glucose kinase

@article{Angell1994GlucoseRI,
  title={Glucose repression in Streptomyces coelicolor A3(2): a likely regulatory role for glucose kinase},
  author={Susan M Angell and Cinzia G. Lewis and Mark J. Buttner and Mervyn Bibb},
  journal={Molecular and General Genetics MGG},
  year={1994},
  volume={244},
  pages={135-143}
}
The glucose kinase gene (glkA-ORF3) of Streptomyces coelicolor A3(2) plays an essential role in glucose utilisation and in glucose repression of a variety of genes involved in the utilisation of alternative carbon sources. These genes include dagA, which encodes an extracellular agarase that permits agar utilisation. Suppressor mutants of glkA-ORF3 deletion strains capable of utilising glucose (Glc+) arise at a frequency of about 10−5 on prolonged incubation. The Glc+ phenotype of the mutants… CONTINUE READING
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