Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets.

@article{Gasa1997GlucoseRO,
  title={Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets.},
  author={Rosa M. Gasa and Ram{\'o}n Morell Gomis and Roser Casamitjana and Francisca Rivera and Anna Novials},
  journal={The American journal of physiology},
  year={1997},
  volume={272 4 Pt 1},
  pages={E543-9}
}
Intracellular pathways by which glucose regulates islet amyloid polypeptide (IAPP) gene expression in pancreatic islets were studied. IAPP mRNA levels were threefold higher in islets cultured with 16.7 mM glucose compared with control (5.5 mM glucose). Mannose and amino acids but not 2-deoxyglucose or 6-deoxyglucose mimicked the effect of glucose. Mannoheptulose (a glycolysis inhibitor) and verapamil and diazoxide (which affect calcium signaling pathway) abolished the difference in islet IAPP… CONTINUE READING