Glucose regulation of insulin gene expression in pancreatic beta-cells.

  title={Glucose regulation of insulin gene expression in pancreatic beta-cells.},
  author={Sreenath S Andrali and Megan L. Sampley and Nathan L Vanderford and Sabire Ozcan},
  journal={The Biochemical journal},
  volume={415 1},
Production and secretion of insulin from the beta-cells of the pancreas is very crucial in maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and exocytosis from the beta-cells in response to changes in blood glucose levels. The synthesis of insulin is regulated by blood glucose levels at the transcriptional and post-transcriptional levels. Although many transcription factors have been implicated in the regulation of insulin gene transcription, three beta-cell… CONTINUE READING