Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes.

@article{Tab2013GlucoseRH,
  title={Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes.},
  author={Bouchra Ta{\"i}b and Khalil Bouyakdan and C{\'e}cile Hryhorczuk and Demetra Rodaros and Stephanie Fulton and Thierry Alquier},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 52},
  pages={37216-29}
}
Hypothalamic controls of energy balance rely on the detection of circulating nutrients such as glucose and long-chain fatty acids (LCFA) by the mediobasal hypothalamus (MBH). LCFA metabolism in the MBH plays a key role in the control of food intake and glucose homeostasis, yet it is not known if glucose regulates LCFA oxidation and esterification in the MBH and, if so, which hypothalamic cell type(s) and intracellular signaling mechanisms are involved. The aim of this study was to determine the… CONTINUE READING
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Glucose Regulates Fatty Acid Metabolism in the Hypothalamus

  • M. J. Wolfgang, S. H. Cha, A. Sidhaye, S. Chohnan, G. Cline, Shulman
  • DECEMBER 27,
  • 2013

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