Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels.

@article{Salpeter2011GlucoseRC,
  title={Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels.},
  author={Seth J. Salpeter and Agnes Klochendler and Noa Weinberg-Corem and Shay Porat and Zvi Granot and Andrew Mark James Shapiro and Mark A Magnuson and Amir Eden and Joseph S. Grimsby and Benjamin Glaser and Yuval Dor},
  journal={Endocrinology},
  year={2011},
  volume={152 7},
  pages={2589-98}
}
Understanding the molecular triggers of pancreatic β-cell proliferation may facilitate the development of regenerative therapies for diabetes. Genetic studies have demonstrated an important role for cyclin D2 in β-cell proliferation and mass homeostasis, but its specific function in β-cell division and mechanism of regulation remain unclear. Here, we report that cyclin D2 is present at high levels in the nucleus of quiescent β-cells in vivo. The major regulator of cyclin D2 expression is… CONTINUE READING