Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change.

@article{Yang2008GlucoseregulatedP7,
  title={Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change.},
  author={Ling Yang and Xiaoyu Liu and Jinyu Hao and Yunlong Yang and Mingxia Zhao and Ji Zuo and Wen Bin Liu},
  journal={Acta biochimica et biophysica Sinica},
  year={2008},
  volume={40 4},
  pages={339-48}
}
Glucose-regulated protein 75 (Grp75) is an important molecular chaperone that belongs to the heat shock protein 70 family and resides predominantly in mitochondria. Grp75 can protect cells from glucose deprivation (GD) injury. However, the molecular mechanisms by which it carries out this function are unknown. Here we report that Grp75 could delay the release of cytochrome c and reduce apoptosis induced by GD, and we also found that Grp75 could decrease Bax/Bcl-2 gene expression ratio and… CONTINUE READING

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