Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell

@inproceedings{Low2013GlucosePR,
  title={Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell},
  author={Jiun Tsuen Low and Justin M. Mitchell and Oanh Hoang Do and Jacinda Bax and Alicia Rawlings and Michael Zavortink and Garry P. Morgan and Robert G. Parton and Herbert Y Gaisano and Peter Thorn},
  booktitle={Diabetologia},
  year={2013}
}
In dispersed single beta cells the response of each cell to glucose is heterogeneous. In contrast, within an islet, cell-to-cell communication leads to glucose inducing a more homogeneous response. For example, increases in NAD(P)H and calcium are relatively uniform across the cells of the islet. These data suggest that secretion of insulin from single beta cells within an islet should also be relatively homogeneous. The aim of this study was to test this hypothesis by determining the glucose… CONTINUE READING
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