Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats.

@article{Wall1989GlucoseOR,
  title={Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats.},
  author={Stephen R. Wall and Gary D Lopaschuk},
  journal={Biochimica et biophysica acta},
  year={1989},
  volume={1006 1},
  pages={97-103}
}
The effect of fatty acids and the carnitine palmitoyltransferase I (CPT I) inhibitor, Etomoxir, on myocardial glucose oxidation in diabetes was studied. 14CO2 production from 11 mM [14C]glucose was measured in control or 6-week streptozotocin-diabetic isolated working rat hearts perfused with or without 1.2 mM palmitate (bound to 3% albumin). In control hearts, addition of palmitate to the buffer resulted in a marked reduction (13-fold) in glucose oxidation rates. Glucose oxidation in diabetic… CONTINUE READING

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