Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas.

@article{Pagliara1974GlucoseMO,
  title={Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas.},
  author={Anthony S. Pagliara and Susan N Stillings and B A Hover and Donna M. Martin and Franz M. Matschinsky},
  journal={The Journal of clinical investigation},
  year={1974},
  volume={54 4},
  pages={
          819-32
        }
}
Interactions between glucose and arginine and a mixture of 20 amino acids found in normal rat serum were studied in the isolated perfused rat pancreas of normal rats, with release of immunoreactive glucagon and insulin as parameters. Secretion of both pancreatic hormones was low during the steady state, whether glucose (5 mM) was included in the perfusion medium or not. This glucose concentration significantly stimulated insulin release twofold and resulted in an 80% inhibition of basal… CONTINUE READING
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