Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.

@article{Macfarlane1994GlucoseMT,
  title={Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.},
  author={Wendy M Macfarlane and Martin L. Read and M B Gilligan and Iwona J. Bujalska and Kevin Docherty},
  journal={The Biochemical journal},
  year={1994},
  volume={303 ( Pt 2)},
  pages={625-31}
}
In the human insulin gene, three regulatory sequences upstream of the transcription start site at -77 (the CT1 box), -210 (the CT2 box), and -315 (the CT3 box) bind a beta-cell-specific transcription factor, IUF1. Recent studies have mapped a glucose response element to a CT-like sequence in the rat insulin I gene. The present study was therefore undertaken to ascertain the role of IUF1 in glucose-stimulated insulin gene transcription. IUF1-binding activity was measured by electrophoretic… CONTINUE READING

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