Glucose modulates the amount, but not the kinetics, of insulin released by sulfonylureas.

@article{Gregorio1994GlucoseMT,
  title={Glucose modulates the amount, but not the kinetics, of insulin released by sulfonylureas.},
  author={Franco Gregorio and Franca Ambrosi and Paolo Filipponi and Sonia Cristallini and Fausto Santeusanio},
  journal={Journal of diabetes and its complications},
  year={1994},
  volume={8 4},
  pages={204-12}
}
This study compares the insulin-secretory profiles induced by therapeutical concentrations of four different sulfonylureas--tolbutamide, gliquidone, gliclazide, and glibenclamide--and the amount of hormone released by each under different ambient glucose concentrations, using the isolated perfused rat pancreas model. All four sulfonylureas stimulated B-cell function, but the kinetics varied. Tolbutamide, gliquidone, and gliclazide produced a quick, biphasic release, whereas glibenclamide… CONTINUE READING
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