Glucose-modified proteins modulate essential functions and apoptosis of polymorphonuclear leukocytes.

@article{Cohen2001GlucosemodifiedPM,
  title={Glucose-modified proteins modulate essential functions and apoptosis of polymorphonuclear leukocytes.},
  author={Gerald Cohen and Michael Rudnicki and Felix Walter and Toshimitsu Niwa and Walter Hermann H{\"o}rl},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 6},
  pages={1264-71}
}
Any modulation of the activity of polymorphonuclear leukocytes (PMNL) is a potential cause of the altered immune response in uremia. Because the level of glycation products is elevated in uremic sera and peritoneal effluents, the effect of glycated proteins on essential functions and on apoptosis of PMNL was investigated. Proteins from sera of healthy donors were incubated with and without glucose. The extent of early glycation was monitored by boronate chromatography and the fructosamine assay… CONTINUE READING